THE 5-SECOND TRICK FOR METHADONE TABLETS

[61] Like quite a few other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with various potency. Dextromethadone, and that is significantly less powerful as an opioid, is much more strong at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone has a lower affinity, with an